CLOZAPINE N-OXIDE ( Clozapine N-oxide )

产品货号. M18447 CAS No. 34233-69-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CLOZAPINE N-OXIDE
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

氯氮平 N-氧化物是氯氮平的主要代谢物，可在氯氮平给药后最早的排泄时间间隔内检测到。
产品描述

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo.
体外实验

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体内实验

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同义词

Clozapine N-oxide
通路

Others
靶点

Other Targets
受体

Others
研究领域

Neurological Disease
适应症

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CAS Number

34233-69-7
分子量

342.82
分子式

C18H19ClN4O
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 100 mg/mL 291.70 mM; Methanol : ≥ 28.6 mg/mL 83.43 mM H2O : 1 mg/mL 2.92 mM
SMILES

Clc1ccc2Nc4ccccc4C(=Nc2c1)N3CC[N+]([O-])(C)CC3
化学全称

3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

1. Dain, J.G., et al. Biotransformation of clozapine in humans. Drug Metabolism and Disposition 25(5), 603-609 (1997).

计算器

产品手册

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